Fountain of Life
HMR Lignan — Nature’s Endocrine Harmoniser
HMR Lignan (7-hydroxymatairesinol) is a plant-derived compound found in Norway spruce knots. When consumed, gut bacteria convert it into enterolactone — a powerful phytoestrogen with documented anti-inflammatory, antioxidant, and hormone-modulating properties. Research spans neuroprotection, cardiovascular health, breast and prostate cancer prevention, and beyond.
Peer-Reviewed Studies
12
Published research
Total Citations
684
Academic references
Body Areas Covered
9
Distinct health domains
Research Period
2002–2020
Publication years
Select a body area to filter studies
All Research
12 studies
Neuroprotective effects of HMR in a rodent model of Parkinson’s disease, modulating inflammatory cytokines in neural tissue and providing antioxidant protection against oxidative neuronal damage.
Giuliano, Siani, Mus, Ghezzi, Cerri et al.
Estrogenic activity documented via metabolite enterolactone, with mild pro-estrogenic effects relevant for hormonal balance and climacteric syndrome improvement.
Cosentino, Marino, Ferrari, Rasini et al.
Pharmacokinetics study showing significant serum enterolactone elevation in postmenopausal women following HMR supplementation.
Udani, Brown, Tan et al.
Anti-inflammatory effects in human aortic endothelial cells, blocking MAPK/NF-kB cascade while activating Nrf2/HO-1 cytoprotective pathway.
Spilioti, Holmbom, Papavassiliou et al.
MAPK/NF-kB blockade and Nrf2/HO-1 activation confirmed, reducing systemic TNF-alpha-mediated inflammation and lipid peroxidation.
Yang, Xiao, Su, Huang, Qin, Wu
Improves body weight, fat and sugar metabolism through gut microbiome synergy — HMR is converted to enterolactone by beneficial bacteria.
Biasiotto, Zanella, Predolini, Archetti
Anticancer effects demonstrated in prostate cancer xenografts. Enterolactone interferes with androgen-dependent tumour growth pathways. Highest-cited HMR study.
Bylund, Saarinen, Zhang et al.
Immunomodulatory activity with chemopreventive profile, showing superoxide radical scavenging and systemic inflammation reduction.
Cosentino, Marino, Maio et al.
Enterolactone exposure associated with reduced proliferation in estrogen-receptor positive breast cancer cell lines.
Kangas, Saarinen, Mkel et al.
Comprehensive analytical characterisation of HMR lignan from Norway spruce, establishing standardisation methods for supplement quality.
Smeds, Eklund, Willför
Detailed mechanism of enterolactone’s estrogen receptor modulation — acts as a weak phytoestrogen competing at receptor sites.
Saarinen, Penttinen, Mäkelä et al.
Norway spruce knotwood identified as the richest known natural source of HMR lignan, providing the sustainable basis for supplementation.
Willför, Hemming, Reunanen, Holmbom
Quality & Purity
Independent verification and testing
Lignan Purity Assay
Analytical Chemistry Lab
HPLC-verified HMR lignan concentration and purity in every production batch, ensuring consistent therapeutic dosage.
Sustainable Sourcing
Forestry Certification
Norway spruce knotwood sourced from sustainably managed forests with full chain-of-custody documentation.
Contaminant-Free
Third-Party Lab
Tested for pesticides, heavy metals, and microbial contamination. All results below detection limits or within strict safety thresholds.
From Spruce Knots to Cellular Health
The Fountain of Life formula centres on HMR lignan (7-hydroxymatairesinol), extracted from the knotwood of Norway spruce trees. These knots contain the highest natural concentration of HMR lignan found anywhere in nature — up to 1,000 times higher than in most edible plants.
When you consume HMR lignan, beneficial gut bacteria (particularly Lactobacillus and Bifidobacterium species) convert it into enterolactone, a mammalian lignan with potent biological activity. This conversion process means that gut health directly impacts the effectiveness of lignan supplementation, creating a symbiotic relationship between the supplement and your microbiome.
The enterolactone produced acts as a selective estrogen receptor modulator (SERM), binding to estrogen receptors with much weaker activity than endogenous estradiol. This competitive binding is the basis for its anti-inflammatory, antioxidant, and anti-proliferative effects across multiple body systems.
Key Points
Products
Available and upcoming offerings
Fountain of Life Capsules
Coming SoonStandardised HMR lignan capsules from Norway spruce knotwood extract. 60 capsules per bottle.
- ✓Standardised HMR Content
- ✓Norway Spruce Extract
- ✓Vegetarian Capsules
- ✓Sustainably Sourced
Fountain of Life Liquid
Coming SoonHigh-bioavailability liquid extract for enhanced absorption. 30-day supply per bottle.
- ✓Enhanced Bioavailability
- ✓Liquid Format
- ✓Easy Dosing Dropper
- ✓No Artificial Additives
External Resources
Further reading and research databases
These statements have not been evaluated by the Therapeutic Goods Administration (TGA) or the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease. The information provided is for educational purposes only and is based on published peer-reviewed research. Always consult a qualified healthcare professional before starting any supplement.