Molecular Hydrogen

H₂ acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals (•OH and ONOO⁻) while preserving beneficial ROS. Landmark study establishing hydrogen's selective antioxidant mechanism.

Ohsawa, Ishikawa, Takahashi et al.

Consumption of molecular hydrogen prevents stress-induced cognitive impairments in animal models, demonstrating neuroprotective benefits.

Nagata, Nakashima-Kamimura et al.

H₂-loaded eye drops protect retinal ganglion cells from ischemia-reperfusion injury, opening possibilities for glaucoma treatment.

Oharazawa, Igarashi, Yokota et al.

Hydrogen-rich water decreases serum LDL cholesterol and improves HDL function in metabolic syndrome patients.

Hayashida, Sano, Kamimura et al.

H₂ reduces cardiac injury during ischemia-reperfusion events, protecting myocardial tissue from oxidative damage.

Song, Suzuki, Fujimoto et al.

H₂ inhalation ameliorates ventilator-induced lung injury by reducing inflammatory cytokines and oxidative markers.

Huang, Liu, Shao et al.

H₂-rich saline attenuates airway inflammation in an asthma model, reducing neutrophil infiltration and cytokine release.

Xie, Yu, Zheng et al.

Hydrogen water ameliorates Con A-induced hepatitis, demonstrating hepatoprotective effects through anti-inflammatory mechanisms.

Kajiya, Silva, Seki et al.

Drinking hydrogen water suppresses liver fibrogenesis, supporting long-term liver health and detoxification function.

Nakao, Toyoda, Sharma et al.

Saturated hydrogen saline protects against intestinal ischemia, maintaining mucosal barrier integrity under stress conditions.

Zheng, Mao, Ye et al.

H₂ alleviates cisplatin-induced nephrotoxicity without compromising antitumor activity — a critical finding for cancer therapy support.

Nakashima-Kamimura, Mori et al.

Hydrogen-rich water reduces lactic acid and muscle fatigue in elite athletes, improving performance recovery times.

Aoki, Nakao, Adachi et al.

Hydrogen-rich water affects body composition and metabolic function in athletes, supporting training adaptations.

Ostojic, Stojanovic

H₂-rich water bathing reduces UV-induced skin damage and wrinkle formation through free radical neutralisation.

Kato, Saitoh, Iwai et al.

Hydrogen-rich water reduces type I collagen degradation in UV-treated fibroblasts, supporting skin structural integrity.

Ishibashi, Sato, Rikitake et al.

Comprehensive review of over 600 H₂ studies confirming safety profile with no known toxic dose or adverse effects at therapeutic concentrations.

Ono, Nishijima, Ohta et al.

Hydrogen-rich water supplementation shows broad clinical benefits including reduced fatigue, improved mood, and enhanced quality of life metrics.

Nicolson, de Mattos, Settineri et al.

Comprehensive review of hydrogen gas biology establishing molecular mechanisms: gene expression modulation, signal transduction, and protein modification.

LeBaron, Laher, Kura, Ohta